On Jennifer's orders, Yorick and Agent 355 search for a geneticist who can unravel the mystery of how he survived. Meanwhile, Hero and Sam encounter a dangerous group of women.

Yorick, Agent 355 and Dr. Mann hit a snag on their way to San Francisco. As the search for 355 heats up, Jennifer clashes with former cabinet secretary Regina Oliver, who has her eyes on the presidency. Hero is seduced by a charismatic leader, Roxanne, as Sam and Nora grapple with their place in a dangerous group of survivors.

Tensions at the PriceMax spiral out of control. Hero and Sam pass the point of no return. Nora uncovers dangerous secrets.

As tensions at the Pentagon come to a head, Jennifer faces a threat. The Amazons hit the road.

As the Amazons close in on Marrisville, Nora reaches a breaking point. Yorick makes a new connection while 355 faces her past.