After a bomb explosion devastates a residential apartment building, special agents Maggie Bell and Omar Adom “OA” Zidan of the New York office of the Federal Bureau of Investigation investigate a possible war between rival gangs – that is, until their prime suspects are discovered brutally murdered.

After eight people are fatally poisoned at a deli in New York City, special agents Maggie Bell and OA Zidan trace the crime to an unlikely culprit and conduct a sting operation to prevent further attacks.

Special Agents Maggie Bell and OA Zidan investigate the death of a safety inspector and its possible connection to a leak at a nuclear power plant.

After a bomb detonates at a restaurant in Queens, the case becomes personal for OA, who grew up eating there. But what initially seems like a terrorist attack reveals itself to be more complex, and OA goes undercover to prevent another incident.

A bank holdup leads the team to a safe deposit box, the contents of which have the potential to destroy national security; Kristen is eager to get back into field work while other team members still have their concerns.

Maggie, OA and the team must stop a hacker who is disabling life-saving equipment in several New York City hospitals. Jubal's son waits for important surgery at one of the impacted hospitals.

After a mysterious bioweapon leaves two MTA workers dead and one injured, the team rushes to determine who is behind the attack and the location of their next target; Jubal’s past demons begin to surface.