1994. With the AIDS epidemic reaching fever pitch, Blanca finds purpose working as a nurse's aide, but Blanca's history with a new patient leads to a challenging ordeal. Lemar shakes up the community when he becomes father to the unruly House of Khan.

When Pray Tell's alcoholism leads to expected consequences, Blanca stages a much-needed intervention. Meanwhile, Blanca nervously prepares to meet Christopher's parents.

After she is unjustly arrested, Elektra convinces Blanca to aid in disposing of the trunk in her closet before law enforcement finds it.

After a startling health update, Pray Tell returns home to reconnect with his birth family.

A visit from an old friend complicates Angel and Papi's wedding plans. Meanwhile, Elektra expands her business with the help of her new, shady, associates.

While the dust settles on their unforeseen life change, Papi adjusts to being a guardian and Angel seeks guidance from an unexpected source

When Blanca discovers an HIV clinical trial is denying access to people of color she joins ACT UP in an effort to get Pray Tell the medication.