When one of the doctors is found unconscious in an elevator at Chastain, the staff frantically retraces his steps to figure out the cause. Billie is faced with a personal conflict when she comes face-to-face with the secret she has been hiding all these years. Meanwhile, Bell helps Kit make a decision about a new neurosurgeon joining the team at Chastain.

Conrad brings a patient into the hospital who causes a high security crisis. An MMA brawl sends a well-known fighter to Chastain and all hands are on deck. Meanwhile, Bell and Raptor vie for the same position at the hospital, and Leela gets a visit from her sister.

When one of the doctors is shot outside the hospital, the ER is put into lockdown and the team races to save one of their own. Elsewhere, Devon and The Raptor work with a patient who learns he is unable to receive a lung transplant, due to his vaccination status. Meanwhile, Devon and Leela try to juggle the new dynamics of their relationship and Cade's father arrives at Chastain.

Conrad comes face to face with Nic's dad, Kyle, after 5 years of no contact, when he comes into Chastain with an extremely low heart rate. Billie advises her patient against surgery, but the patient’s family ignores her recommendation. Meanwhile, Cade musters up the courage to confront Ian about his addiction and Leela grows concerned about Padma.