Conrad brings a patient into the hospital who causes a high security crisis. An MMA brawl sends a well-known fighter to Chastain and all hands are on deck. Meanwhile, Bell and Raptor vie for the same position at the hospital, and Leela gets a visit from her sister.

A new group of interns, which include Billie’s son, Trevor, start their first day with Devon at Chastain. Kit and Bell try to convince Conrad to come back to Chastain and The Raptor’s mom ends up back in the ER. Meanwhile, Leela and Padma deal with an unexpected visit from their parents.

Conrad takes Trevor under his wing to care for a patient whose good luck seems to have run out. Leela struggles when given the decision to take full responsibility of her indecisive patient's life and The Raptor continues to try to figure out a care plan for his mother. Meanwhile, both Devon and Kit are stretched far too thin trying to balance everything on their plates

When things from Billie's past begin to come to light, she is the subject of whispers and stares around the hospital and the team struggles to find the best way to support her. With the nurse shortage in full swing, a simple cleaning job turns into a horrific disaster that calls for all hands on deck. Meanwhile, Trevor discovers a shocking secret and Padma has a proposal for Leela

As his clinical begins, Devon treats his first patient with a revolutionary medical fluid that doesn’t go as planned. Meanwhile, an overdosed John Doe is rushed to Chastain, leading Conrad straight into a much bigger scandal than he expected. Then, a shocking secret regarding Cade’s past is discovered.

Conrad treats one of Gigi's fellow classmates whose stomachache turns into something much more serious; Devon takes several interns to a senior living facility; Leela uncovers some unsettling news.

With Raptor on leave to take care of his mother, the hospital scrambles to stay organized without him. Meanwhile, a camping trip leaves a patient with a fatal disease that none of the doctors have seen before. Then, Bell and Kit devise a plan to help their case with the Medical Board.

Conrad and Cade work with a Medicare patient who sheds some light of prescription fraud. Leela works herself to the brink of exhaustion.

Conrad contemplates his future; Devon is presented with an amazing career opportunity out of state; Ian is faced with a devastating diagnosis; Kit and Bell celebrate their engagement; Padma receives some highly anticipated news.

When Padma's pregnancy takes a dangerous turn, the doctors come together to find a solution and turn to Ian to perform a miracle. Meanwhile, Conrad makes a decision regarding his love life and Devon leads his own clinical trials at Chastain.

The high stakes governor election results in violence at the polls, causing multiple victims to arrive at Chastain. Conrad finds common ground with an aggressive patient, helping lead to a diagnosis for his outbursts. Meanwhile, when another patient’s lung collapses, the doctors find a serious root of the issue.

When a gunshot victim comes into the ER, his injuries prove to be so catastrophic throughout his body that multiple doctors need to jump on the case. Meanwhile, Ian is faced with a mandatory drug test and Padma prepares for her C-section.

Ian is faced with performing a surgery on a Jane Doe NICU patient while he continues to struggle with his personal issues. Meanwhile, Conrad asks Devon to cover his shift so he can spend a day at home with an anxious Gigi.

A college professor comes into the ER and Conrad realizes it’s a former patient of his from when he was an intern. Meanwhile, Devon ends up admitting a man – who swears by an anti-aging regimen that he thinks is the answer to eternal life – into the hospital after he collapses.

Devon prepares to perform the first titanium rib cage implant surgery in the country.

Conrad comes face to face with Nic's dad, Kyle, after 5 years of no contact, when he comes into Chastain with an extremely low heart rate. Billie advises her patient against surgery, but the patient’s family ignores her recommendation. Meanwhile, Cade musters up the courage to confront Ian about his addiction and Leela grows concerned about Padma.

A famous cardiothoracic surgeon – who happens to be Dr. Yamada’s mentor – comes into Chastain after experiencing heart pain. Meanwhile, Kit breaks the news that the ER will no longer be accepting trauma patients due to budget cuts, and Devon and Conrad help treat a confused woman.

The ER quickly fills up after a heavy storm causes a devastating helicopter crash. Conrad, Devon and the rest of the Chastain doctors rush to treat patients including the helicopter pilot, a barista, and Chastain’s least favorite person, Governor Mark Betz.

Conrad is pulled away from celebrating Gigi’s 6th birthday when Sammie comes into Chastian with a 104-degree fever, and Kit must call in a favor for treatment. Meanwhile, a heart arrives for Governor Betz’s transplant surgery.