A blackout at Chastain Memorial Hospital requires the staff to treat their patients without the help of any technology. Bell orders the staff to stop accepting new patients and transfer those on life support, but when a child in need is rushed to the ER, Conrad and Devon go against the mandate. Meanwhile, Mina and Austin are tasked with performing heart surgery on a premature baby, despite the lack of power, and Nic works tirelessly to organize the staff and patients who stay during the blackout.

When Bell makes the executive call to utilize Julian Booth's medical devices, rather than the hospital's usual products, Kit and AJ must stop their momentary feuding in order to team up against him. Elsewhere in the hospital, Conrad and Nic work to make a child's dreams come true after finding out his cancer has returned and the rest of the staff takes notice of Julian and Devon's new friendship.

When Conrad's attempt to surprise Nic with a lavish Valentine's Day dinner is foiled, he gives the reservation away to someone who could really use it. Mina and Devon distract themselves from all Valentine's celebrations by trying to figure out how their seemingly healthy neighbor has suddenly passed away. Meanwhile, Kit gives dating advice to a sex-injured patient, Irving hits a crossroads in his not-so-secret relationship with Nurse Jessica, and Bell decides to celebrate the day in the OR.

When the hospital has a severe blood shortage, Conrad must try every avenue to save a patient's life. Nic receives devastating news and is left worrying about her sister's health, while Mina and Devon work with a new anesthesiologist who is not what she seems. Elsewhere, Kit considers the future of her intertwining relationships and Bell has an encounter with a woman from his past.

The doctors of Chastain are surrounded by new rules and doctors, as Red Rock Mountain Medical takes over the hospital. Conrad finds himself in a dangerous situation when the construction for a new neurosurgery center causes a gas explosion.

Devon and Irving are inundated with patients in the ER. When an A-list celebrity enters the hospital after swallowing a wishbone, Logan Kim assigns a new surgeon to the case in the hopes of garnering extra publicity.

Devon and Conrad face a moral dilemma over a suicidal patient who is in need of a liver transplant.

A renowned pediatric cardiac surgeon proves unfit for surgery. A Dolly Parton drag queen collapses on stage. Nic and Conrad suspect a patient may be the victim of sex trafficking. Nadine delivers some surprising news to Devon.

Conrad finds himself caught between his duties as a doctor and his loyalty to Kit when he discovers that her son-in-law may be suffering from a serious disease. Devon and Nic make a shocking discovery about a former patient.

After a long wait, Conrad and Nic prepare for their wedding day with the support of their family and friends. Meanwhile, flashbacks to the early days of the COVID-19 crisis shine a light on the heroism of the doctors and the toll the virus took on everyone at Chastain Memorial.

The wait is over as Conrad and Nic welcome the arrival of their baby girl. Raptor's life begins to fall apart and he is forced to turn to Cain for help. Devon and Bell work together on a complicated surgery that may allow them to save multiple lives. Kit tries to deal with the moral repercussions of financially saving Chastain.

A college professor comes into the ER and Conrad realizes it’s a former patient of his from when he was an intern. Meanwhile, Devon ends up admitting a man – who swears by an anti-aging regimen that he thinks is the answer to eternal life – into the hospital after he collapses.