When Atlanta is struck by a severe snowstorm, Mina must perform a big surgery - without the help of The Raptor - to save the life of a young father, while Kit and Bell get stuck babysitting the man's children. Nic and Conrad experience a disagreement with a patient's treatment, causing further strain in their relationship. Meanwhile, Devon teaches an important lesson about life and death to a first-year med student.

The doctors work to save one of their own but disagree over what's best for her. Bell is met with an unexpected response when he voices concerns regarding the nursing shortage that Nic brought to his attention.

Cain recruits Ezra to help keep an emergency situation under wraps. Nic works to come up with a support system for a patient in need of a lung transplant. Kit's son-in-law's condition continues to worsen.

Just when Mina and The Raptor can see their future together, an unexpected complication throws a wrench in their plans. Meanwhile, Cain faces a harsh reality when Kit gives him the opportunity to prove he is ready to return to the OR. Then, Devon presents Rose with a groundbreaking clinical trial that could help her battle with Sickle Cell Anemia.

On the day of Nic's baby shower, Billie takes full control to make sure it goes smoothly, but a secret she's been hiding changes everything. Devon and Leela stumble upon an apartment fire, where they assist in getting victims safely to Chastain and Leela gets a chance to prove her skills to Raptor. Jake and his husband deal with the complications of Sammie's health. Raptor and Rose receive exciting news.

When one of the doctors is found unconscious in an elevator at Chastain, the staff frantically retraces his steps to figure out the cause. Billie is faced with a personal conflict when she comes face-to-face with the secret she has been hiding all these years. Meanwhile, Bell helps Kit make a decision about a new neurosurgeon joining the team at Chastain.

A case turns personal for Conrad when the donor recipient of Nic's heart is admitted to the ER. Bell is faced with a devastating diagnosis that causes him to make a heartbreaking decision. Meanwhile, the Raptor asks Devon to include his ailing mother in his clinical trial, causing Devon to face a major dilemma