Conrad, Kit, Mina and the Raptor work to save the life of a med student in need of a triple-organ transplant, drawing Bell back to the OR for one of the Chastain's riskiest surgeries yet. After the police find Julian's empty car in a nearby lake, Devon does some investigating of his own to find out what might have happened. Meanwhile, Mina and the Raptor hound Bell to halt his business with the risky medical device company, Quovadis, and Nic makes a rash decision regarding her sister.

When Atlanta is struck by a severe snowstorm, Mina must perform a big surgery - without the help of The Raptor - to save the life of a young father, while Kit and Bell get stuck babysitting the man's children. Nic and Conrad experience a disagreement with a patient's treatment, causing further strain in their relationship. Meanwhile, Devon teaches an important lesson about life and death to a first-year med student.

Conrad comes under fire when a former patient files a malpractice lawsuit against him, putting Bell in a difficult position with Red Rock. The doctors perform a risky brain surgery. Mina discovers that Adaku has a dangerous heart condition.

A renowned pediatric cardiac surgeon proves unfit for surgery. A Dolly Parton drag queen collapses on stage. Nic and Conrad suspect a patient may be the victim of sex trafficking. Nadine delivers some surprising news to Devon.

After a long wait, Conrad and Nic prepare for their wedding day with the support of their family and friends. Meanwhile, flashbacks to the early days of the COVID-19 crisis shine a light on the heroism of the doctors and the toll the virus took on everyone at Chastain Memorial.

When a tornado touches down in Atlanta with Chastain directly in its path, the entire staff goes into crisis mode. Conrad and Nic work on an injured EMT. Devon and Leela become trapped with a man who has severe head trauma.

A case turns personal for Conrad when the donor recipient of Nic's heart is admitted to the ER. Bell is faced with a devastating diagnosis that causes him to make a heartbreaking decision. Meanwhile, the Raptor asks Devon to include his ailing mother in his clinical trial, causing Devon to face a major dilemma

When Conrad confronts a pharmacy owner about fraudulent prescriptions being filled under his name, the situation takes a dangerous turn; the ER is sent into chaos when a street racing accident results in multiple severe injuries.

Devon sees a traveling British couple who are nervous about the cost of American health care.