MI5 security officer Eve Polastri is bored in her job and yearns for a more exciting life. When a Russian politician is murdered, Eve is tasked with protecting the only witness and soon finds herself on a collision course with a violent and extraordinary assassin, Villanelle.

In the aftermath of her recent assignment, Villanelle is ordered to take a break. Never one to do as she's told, she goes ahead with her next mission regardless. Meanwhile, Eve is given a dream opportunity to join a secret MI6 unit tracking Villanelle and the shady organization she works for.

When Villanelle kills a Chinese colonel at a kink clinic in Berlin, Eve and Bill travel out to investigate. While Eve and Bill chase up a number of promising leads, Villanelle enjoys the cat-and-mouse of their proximity. But as they draw closer, Eve comes to realize that this is much more than a game.

Intel from Berlin points to the existence of a mole, prompting Eve to undertake her first surveillance operation. Meanwhile, Villanelle is sent to England to eliminate a member of British Intelligence. Villanelle wonders, could it be Eve?

Having survived a terrifying close call with Villanelle, Eve now has the mole ensconced in a safe house and is buzzing. They have an exciting opportunity to glean information and crack this thing open.

A female assassin is taken into custody in Russia, and Eve and Carolyn head out to Moscow to negotiate access. She could hold the key to the organization that runs Villanelle. Meanwhile, Villanelle is smuggled into the same Russian jail. It's a grim and brutal place, where not even Villanelle is safe.

Tensions are running high as the situation in Moscow escalates, and Eve starts to question who she can trust. Despite the danger, with her sights firmly set on Villanelle, Eve goes rogue. With both women under pressure, the stakes are higher than ever.

Villanelle's mission is proving anything but straightforward, forcing her to take drastic measures. Meanwhile, Eve makes a shocking discovery, which leads her right to Villanelle and an electrifying confrontation from which neither will emerge unscathed.

Eve sets out for her revenge against The Twelve, even if it kills her. Villanelle tries to reform.

Eve confronts Helene and seeks her aid against The Twelve. Villanelle's attempts to reform continue.

Eve finds the name of Helene's target. Villanelle forces an MI6 psychiatrist to give her therapy.

Eve establishes her boundaries with Villanelle. Helene sets a challenge for Eve.

Eve seeks out any information about The Twelve's origin, but uncovers more than she bargained for.

Eve nurses Villanelle back to health, then heads to Berlin to try to take her revenge on Lars.

Eve begins to question her identity and her actions, and she rekindles a relationship with Gunn.

Eve recruits Villanelle for revenge against The Twelve, even at the cost of their own lives.