The Matsuno brothers struggle to find employment. Later, Osomatsu tries to take an interest in his brothers' lives but winds up being a nuisance to them.

Wanting to become the main protagonist of the franchise again, Iyami holds a bizarre kart race to determine who the protagonist of Osomatsu-san will be.

Noticing Matsuzou acting strangely, the siblings discover that he is worried that there's not enough spark in his marriage with Matsuyo. Feeling he should return to a more innocent time, the boys give Matsuzou a masterlcass in being a virgin, albeit with no success. Matsuzou inevitably resorts to getting a love potion from Dekapan, but ultimately decides against using it, managing to sort things out with Matsuyo by himself.

The brothers get rowdy while getting drunk at a restaurant. Unemployed office lady Totomi ends up taking a job at a strange establishment that offers some peculiar services. After being visited by a salesman, Matsuyo contemplates sending off one of her sons to a NEET correctional facility, asking Choromatsu to help her decide which one to send away.

The Matsus welcome a pair of AI to help them with their daily lives, but do these AI have ulterior motives?