Season 1 of A.P. Bio premiered on February 1, 2018.

When Harvard philosophy scholar Jack Griffin finds himself teaching high school in Toledo, Ohio, he tosses the syllabus and recruits his students to help enact revenge on his rival.

Season 2 of A.P. Bio premiered on March 7, 2019.

Having botched his chance to get out of Toledo last season, disgraced Harvard philosophy scholar Jack Griffin is once again stuck teaching biology class at Whitlock High for the lovable Principal Durbin.

Season 3 of A.P. Bio premiered on September 3, 2020.

Season 4 of A.P. Bio premiered on September 2, 2021.