Jake Murdock wants revenge on Parmalee for sending him to prison. His plot involves Dr. Duvain who has a mind-controlling drug that can make a man kill his best friend. To remove suspicion they plan to have a ranger kill the captain. Reese is picked and undergoes a series of injections to prepare him for the murder. A $5 gold piece is the key to controlling Reese, whenever he sees one he is to obey the next verbal command which results in Reese allowing an outlaw to escape, immersing himself in a horse trough (Go soak your head) and busting up the saloon. Chad investigates the doctor's background and reads books about chemistry and the brain. He figures out what is causing Reese's strange behavior and convinces Parmalee of it who then devises a way for the plan to backfire on Murdock and the doctor.

Parmalee sends Chad and Joe after the Sam Dixie Gang, who Erik has been trailing for two weeks. Meanwhile, Reese is assigned to catch the thieves who stole merchandise from Morgan's Store. He tracks them down and is captured by the thieves, a group of four orphan boys lead by Dixie's teen cousin Matt who wants to join up with Sam Dixie's gang. Erik has been romancing Dixie's girl Mollie and while searching for the Dixie Gang runs into Reese and the orphans. Sam Dixie eventually meets up with the orphans but wants nothing to do with them. Reese managed to save the life of Midg the youngest of the boys and the orphans are determined to keep Sam Dixie from killing Reese. Is the Dixie Gang strong enough to do battle with two Texas Rangers and four orphan boys?