A string of burglaries hits close to home for Murtaugh when one occurs in his own neighborhood, and it gets just as personal for Riggs when another break-in ends in a casualty. Roger Junior connects with an old friend who might be twisted up in some criminal action of his own.

Murtaugh delves deep into the psyche of a former navy seal who is wanted for criminal activity, and draws parallels between him and his partner, Riggs, who also served in the military. Riggs' connection to the suspect threatens to interfere with the case, but it also forces him to open up to Murtaugh.

A brutal car crash reveals that Cahill is the target of a murderous stalker, causing Riggs and Murtaugh to turn the tables and start asking her questions for a change. After finding Murtaugh's file in Cahill's office, Riggs becomes obsessed with finding out about his. Roger and Trish reel over their daughter's newfound fake ID.

Riggs and Murtaugh are led into the underground mob world as they investigate a murder in a hospital. Murtaugh learns that Riana is secretly dating his neighbor and nemesis' son. Riggs spends more time with his childhood friend. Scorsese's real name is revealed.

Murtaugh and Riggs respond to the murder of an escaped patient of Dr. Cahill's who mysteriously goes off the rails. Riggs' anger gets the better of him once again, causing Avery to consider whether or not he is fit to serve. Family tension runs high between Murtaugh and Trish, who have to make big decisions about R.J.