Dr. Rhodes and Dr. Choi clash over the final decision made by a dying patient. Meanwhile, a pending lawsuit against Dr. Halstead moves forward, and doctors race to save a patient with a misdiagnosed flesh-eating bacterial disease.

Dr. Manning's actions with a recent patient lead to serious repercussions. April and Noah disagree over a patient who is injured after a beating. Dr. Charles is visited by a childhood friend with a surprising revelation.

The crossover starts on Chicago Fire S08E04 Infection (I). It continues on Chicago PD S07E04 Infection, Part III (III).

Halstead and Asher clash over a patient in need of a kidney transplant. Marcel faces a tough decision when Blake is in surgery. Choi and Archer treat the son of Med's general counsel. Med's family grows.