Brandy and her friends are playing truth or dare when they hear some screams. When they investigate the issue, they discover another dog and rabbit, Sandy Carrington and Mr. Frisky, who have landed in the Amazon after Mr. Frisky accidentally opened the plane's cargo door. However, Sandy & Mr. Frisky are the best of friends and they soon work together to become the two most popular individuals in the entire Amazon. Unfortunately, Brandy & Mr. Whiskers become jealous over the fact that Sandy & Mr. Frisky does everything better than them, so they decide to formulate a plan to ruin their reputation.

Whiskers finds Brandy's favorite soft toy from when she was younger, and annoys and embarrasses her by convincing her to play with 'Itty Bitty Kitty' once again. When Brandy gets infuriated, Mr Whiskers gives the toy to Gaspar, though Brandy tries to get it back.