The trail of a mysterious organization called the “Army of the 12 Monkeys” leads Cole to a mental institution in 2015, where a patient holds the key to the plague that destroys the world. Meanwhile, despite warnings that her involvement may disrupt the course of history, Dr. Railly risks her life to help him.

Cole's search for the location of the virus leads him to 2014, and to a devastating moment in Dr. Railly's life involving a dangerous outbreak in Haiti.

Cole and Dr. Railly face off with the Army of the 12 Monkeys when both discover the Night Room –- an off-site, black ops lab that houses the virus that will one day destroy the world.

When the tragic events of the Night Room create an alternate reality in 2043, Cole risks his future.

Cole, Dr. Railly and Aaron strive to stop the virus from being deployed as a bioweapon in Chechnya.

Cole splinters to Tokyo, 1987 in a last chance effort to stop the Army of the 12 Monkeys.

With Cole dying from the effects of time-travel, Railly must find the one person who can save him.

When Cole and Cassie are stranded in 1944, Jones must turn to the person she trusts the least to bring them home -- Ramse. For Ramse, this mission will give him a chance to atone for his sins -- but can he mend the broken relations between Cole and Railly? Meanwhile, Jones visits Old Jennifer Goines to explore the true nature of Time - and the Twelve’s method to destroy it.

In the present, Cassie and Jennifer Goines run from the 12 Monkeys; in 2044, Cole and Ramse face off against Deacon.

To save the last Primary, Cole must turn to a mortal enemy. Plus: Jennifer Goines, radical revolutionary?

Cole and Railly have finally found peace living in the past. When a mysterious woman with apocalyptic visions of the future tells Cole it's not over, he must do the unthinkable to save the world... and the woman he loves.

In the apocalypse of 2163, a desperate Cole searches for Titan. Meanwhile, a captive Railly is faced with an impossible choice as the 12 Monkeys await the arrival of The Witness.

While searching for Jennifer Goines in post-WWI France, Cole and Jones encounter a dangerous group of time- travelers - the Guardians.

Bonds of trust are tested when Ramse returns to the facility with an old enemy held captive. How far will Cole and Jones go for the answers they need?

Ramse and Cole splinter to 2007 expecting either a trap - or a final chance to kill The Witness. But when Cole discovers a heartbreaking truth, he’ll discover that the mission was both.

Team Splinter goes back in time to the wild, wild frontier in search of a weapon to destroy the Witness.

The beginning of the end as Cole and Cassie embark on their final mission.