Old supervillains break out of the retirement home, and the Powerpuff Girls get old superheroes out of retirement to beat them.

Bubbles and Buttercup do Blossom's hair, but when it gets tangled they give Blossom a bad hair day.

The Professor has to go out to an award's ceremony. He forgets to call the babysitter so he calls the Mayor who calls up Mojo Jojo to babysit.

The Professor gets a new job, and the Utonium family moves to the Town Of Citysville. The Professor loves it, but the girls' don't and are having a hard time to adjust to the new changes.

Bubbles has problems seeing, so she's forced to wear glasses.

Princess buys Townsville and makes crime legal.

Ms. Keane assigns pet duty since it's Friday. The Powerpuff Girls volunteer, but she chooses Mitch to take care of Twiggy, the class hamster.

A lazy cop named Mike Bricoski lets his other fellow cops do the dirty work for him, but when he gets fired he takes his revenge out on the Powerpuff Girls.

Blossom and Buttercup have an argument thinking that brains or brawn is the best way to destroy a monster.

Mojo Jojo turns the world into dogs again. The Powerpuff Girls come to the rescue wondering why Mojo does the same plan again. He tells them that he's found a fatal flaw in his old plan as he watches a video of his old plan.

A dumb crook hides a jewel in a cereal box. He searches all 3000 of them and when he's down to his last one the Professor buys it for the girls'.

After some inspiration from their favorite comics Blossom, Bubbles, and Buttercup try to become better heroes.

When the Mayor rewards the Powerpuff Girls with candy for saving the day the girls ask Mojo to commit more crimes, so they can get more candy.

An unbeatable slime monster comes to Townsville.

The Mayor gets sick and tired of the Powerpuff Girls saving the day so he decides to save the day by himself.

The Professor sleepwalks and steals toys at the same time. When the girls' find this out they have fun taking advantage of the situation.

A new villain steals valuable information from smart people in Townsville, so the Powerpuff Girls use the Mayor as his new target.

A female villain named Femme Fatale teaches the girls' to be sexist, so she can get away with crimes.

The Professor tries to spend time with his daughters, but they fight crime to much. To solve the problem the Professor creates a power suit, so he could fight crime and spend time with the girls'.

After receiving a dollar from the Professor, Buttercup gets hooked and steals other people's teeth for the tooth fairy.

Mojo Jojo, Princess Morebucks, Fuzzy Lumpkins, and Him all team up as The Beat Alls to defeat the Powerpuff Girls. All is going well until Mojo Jojo falls in love with Moko Jono who breaks up the Beat Alls.

Bubbles loves animals and the Professor is sick of her bringing them home, but when she brings home a baby whale the girls try to hide him before the Professor comes home.

The Gang Green Gang raids a mini mart eating all types of foods. When the Powerpuff Girls arrive they use their heat vision which causes a chain reaction which gives the Gang Green Gang super powers.