In the opening episode of this nine-part series dramatizing the manhunt of Australian drug kingpin Tony Mokbel, Detective Inspector Jim O'Brien observes Mokbel as the Carlton Crew contend with internal affairs. Meanwhile, Carl Williams vows revenge on the Morans after being injured in a skirmish with them.

Tony and the Carlton Crew import a huge hash shipment; the Victoria Drug Squad shares intelligence with Australian Federal Police agent Jarrod Ragg in a bid to bring down Mokbel and the Carlton Crew.

When a hitman alleges Tony is involved in murder, Tony decides to skip bail and become Australia's most wanted man. Tony takes a massive gamble when he recruits a pair of cleanskins to run his drug empire while he is on the run.

After skipping bail, Tony hatches a risky plan to flee Australia and start a new life in Greece. With Tony on the run, the fight is on for control of his drug empire. The police face a wall of silence in their search for Fat Tony.