Claire's medical expertise proves invaluable, but she begins to fear for her life when tragedy strikes her patients' household. Jamie and Young Ian travel to a nearby town to recruit settlers for Fraser's Ridge.

Roger's diligent search for Brianna pays off when he finds her in Wilmington, but their romantic reunion comes to an abrupt halt when she discovered pertinent information that he intentionally kept from her.

Jamie, Claire and Young Ian embark on a long uncertain journey to rescue Roger, while Brianna forges a friendship with one of Jamie's old friends as she fends off Aunt Jocasta's attempts to secure a husband.

Brianna confronts a violent figure from her past in an attempt to cope with her trauma. Roger befriends a fellow captive and endeavors to escape the Mohawk Village, while Fergus and Marsali plan a dangerous mission.

As Jamie continues to hunt Murtagh with the aid of the zealous Lieutenant Hamilton Knox, he's forced to consider whether or not he's on the right side of history.

The Regulator Rebellion reaches a boiling point, forcing Jamie to face his fear and confront the consequence of his divided loyalties.