Carter plays tour guide for Ruth Johnson, who was born in the hospital 100 years ago to the day, and her large family. Carol treats a boy who was hit by a car and tells a story of being chased, his friend being shot in the process. Peter observes Kotlowitz install a cochlear implant and decides to wait before scheduling an operation for Reese. Mark dines with Dr. Lee, new ER chief. Dr. Corday proposes radical changes in scheduling at an M&M conference, and later decides to break off her relationship with Benton.

Greene flies in a helicopter to a remote area of Indiana to rescue a heart transplant patient. The helicopter develops problems, and Greene arranges for paramedics to transport the patient to County. Because Weaver is gone for the day, Romano appoints Benton in charge of the ER. Kovac is plagued by the death of the mugger.