When a female car accident victim is brought into the ER with a spike through her torso, everyone immediately blames her boyfriend for causing the accident. She makes it through surgery, but the doctors find that she may be paralysed. Later, they discover that the boyfriend has lupus, which could be to blame for the accident. The case brings up painful memories for Will. Emily deals with a model with jaw cancer who refuses to undergo surgery. Emily and Cassandra compete for Will's attention as they all prepare for the in-service exam.

After a year long absence, Dr. A.J. Aquino returns to Denver Memorial, but before he can rejoin the staff, the Chief insists that he make peace with Dr. Bandari. Emily is tasked with treating a patient who claims to be a psychic, and is convinced that her tarot cards predict her own impending death. Elsewhere, Cassandra and Dr. Bandari treat a patient who needs a lung transplant, but Micah’s discovery of a new medical issue leaves the patient with a tough decision. Meanwhile, Emily decides to test her theory that Will was jealous of her recent date, so Tyra offers to teach Emily how to flirt.

When Emily, Will and Cassandra compete against each other to be Dr. Bandari's research assistant, feelings get hurt when they have to describe each other's flaws. Emily is determined to solve the medical mystery of a young patient whose x-rays reveals a bullet lodged in his lung, but who has no signs of a gunshot wound or scar. Meanwhile, Emily comes to a revelation about her personal life after diagnosing a daredevil with a rare disease that forces him to change his entire life.