Mike and Sully run into now-married Kid Cole and Sister Ruth and invite them home for Thanksgiving, but the coach is hijacked, forcing them to journey home, on foot, through Indian country. Also, the Cooper kids scramble to put Thanksgiving supper together. Kid Cole: Johnny Cash. Sister Ruth: June Carter Cash.

Mike volunteers Robert E's services to fix a steam engine for the railroad, but whether Robert E can do it remains in question until the job is completed. Also, Mike solves a medical puzzle when two Chinese railroad workers, the Chang brothers, fall strangely ill. Jackson Tait: Allan Royal. Peter Chow: Eric Michael Zee.

The town invites a traveling all-star baseball team for a fundraising event, but later suspects that they have been swindled. Otis James: Joel Anderson.

At Thanksgiving, Mike faces the possibility that she might be infertile, while Jake struggles with the fact that he has no family to share the day with. Brian becomes attached to the Thanksgiving main course.

The family finds Matthew running a saloon at a railroad camp where his grief over Ingrid's death drives him to volunteer for a dangerous blasting job. Loren loses Dorothy's money for a new printing press. Peter Chow: Eric Michael Zee.

The town is duped by two con men selling shares in a refrigeration box and Mike must turn the tables on the con men, helping the town learn a lesson in trust. Meanwhile, Cloud Dancing barters with Loren to sell corn grown on the reservation at the general store. Randolph Cummings: Brandon Douglas. Curtis Roper: Anthony Lee. Anthony: Brenden Jefferson.

A malpractice suit prevents Dr. Mike from practicing medicine, leaving the reluctant Dr. Cook in charge.

A sick and ragged prospector wanders into town and Jake Slicker recognizes the man as his father, who abandoned him years before.

Dr. Mike, Sully and Matthew team up with a legendary marshal in order to nab the thieves who wounded Matthew during a bank robbery.

When three people die after coming in contact with something in the clinic, and one is deathly sick, Dr. Mike, Sully, Colleen, and Andrew but their heads together to find out what it was. They figure out that it was something in the clinic and now it is everywhere. In her case, on the instruments, the sheet. The only solution is to burn everything. When that is done, some are genorous enough to give Dr. Mike some of there things, but they are scared to come in. When Sully must get stitches, and lives after being treated by Dr. Mike, she begins the road to being reaccepted by Colorado Springs.

In a case of mistaken motivation, a judge sends Sully to prison after he is spotted with criminals bent on stopping the construction of a dam.