Itoshiki Nozomu is always in despair! Even simple things like paying for the toll on the subway can send him to a despair so deep only attempted suicide is the answer. How Strange is it then, that he should be the teacher of a High School Class filled with students with even more emotional problems than his. This great Comedy will leave you in anything but 'Despair' as you meet each of his students and watch their wacky adventures.

故事发生在一个问题班集体——2年へ组中，全班32个学生全部都曾经留过级，被喻为是“绝望的学生们”。

担任该班班主任老师的是一个名叫糸色望的青年男子。

11月4日出生，在家排行老四，戴眼镜，喜欢穿和服，所有的装扮全都是怀旧风，喜欢读书，酷爱太宰治的《人间失格》，

爱好甜食，父母家在信州县藏井泽是当地的旺族，口头禅是“绝望了！××绝望了！”，

因其名连读起来就是“绝望”，故被全班同学戏称为“绝望先生”。