Chie dispatches Nozomu to investigate rumors that the invariably injured Abiru Kobushi is suffering from domestic violence. He pursues Abiru's father while he shops, causing him a great deal of inconvenience, before discovering Abiru's obsession with pulling the tails of dangerous animals. The latter half of the episode concerns Meru Otonashi, who is silent and shy in person, but remarkably abusive via text-messaging, her only means of communication.

This episode begins with Usui Kagerou lamenting about how he never gets noticed by anyone, when he nearly gets run over by a truck who does not notice him. He runs into Nozomu in the shadows, who begins to talk about how some people are destined to be overshadowed by others, no matter how hard they work. The second part of the episode has the class undergo criticism training. Usui continues to be ignored until a divine wind blows away his hair, revealing his bald head and allowing everyone in the class to see him. He fears that people in the class will begin mocking him, but Kafuka suggests that Chie insults him instead, which he seems to enjoy.

The first part of this episode introduces Ai Kaga, a girl who always takes blame for everything, even though it is not her fault. Nozomu takes the class to a "guilt scramble" to explain that history has led to the "guilt complex" such as Kaga's becoming the Japanese mentality. After being overcome with guilt himself, Nozomu and Kaga travel the world to try to stop burdening others. The second part introduces another girl, Mayo Mitama. Her evil-looking eyes have led to her being misunderstood - that is, she actually is evil, but people try not to prejudge her and assume she is actually good. She commits several cruel acts that Nozomu bears witness to and is blamed for, being the only other nearby party. He becomes so concerned with not prejudging that he doesn't blame her when she hits Majiru over the head with an aluminum bat or when she drops a brick onto Nozomu's head.

Nozomu Itoshiki hands out an application for his pension in a government office, but an employee makes fun of Nozomu's name. Nozomu is sick of hearing the same thing about himself over a million times and he sympathizes with other people, who have experienced a similar situation for countless times in their life. Meanwhile, Harumi Fujiyoshi realizes that she is an extreme minority as no one seems to agree with her view. The second part of the episode shows a Zetsubō channel featuring a number of television programs such as audience survey, music show, magical girl anime, cooking show, etc. In the third part of the episode, Nozomu is kicked out of a café, because a Jyuken student is constantly irritated by him. The café manager kindly asks Nozomu to forgive him, because it is generally believed that exam-preparing students should be treated with the utmost care. Though Nozomu can't quite understand this kind of expectation in the Japanese society, he nevertheless tries to take advantage of this trend by becoming an exam-preparing student himself. Eventually, he happens to pass every certificate exams in the world except for one: an exam that tests whether a person is ready enough to commit suicide. However, he fails the exam and thus becomes not worthy enough to live nor worthy enough to die. The third part of the episode is shown using various animation techniques.

Nozomu Itoshiki watches a live baseball game and is reminded of a fact that many baseball stadiums intentionally reduce the flight range of baseball to make the game more enjoyable to watch. He suddenly realizes that such practices of intentional 'detuning' are quite popular in Japanese society. Nozomu points out that some people use 'detuning' as an excuse for their faults, Kafuka explains that people in general feels more comfortable with 'detuned' products rather than the cutting-edge one. In the second part of the episode, Nozomu states that there is an increasing tendency of saying 'not bad, not bad' at terrible things to comfort the victims. However, Nozomu explains that such instance can turn out to be a 'mini-propaganda', which could unknowingly mislead other people to believe in the same way. In the third part of the episode, Nozomu refuses to teach the first period class, because he was previously rejected by a restaurant in Kyoto as he was a first-time customer. He realzies that the Sayonara Zetsubō Sensei anime series could have been difficult series to approach for the first-time audience, so he decides to start the first-time-friendly episode. However, he is annoyed by the constant inquries from the first-time audiences. Thus, he decides to only invite regular audiences, but they seem to knows too much about the series. Ultimately, he decides to also reject the regular audience from the show.

After dismissed from the school as a demon, Nozomu Itoshiki wonders where the devils will end up once they are dismissed from everyone. Nozomu suddenly argues that dismissed people should be provided with a new employment after their dismissal, otherwise dismissed people will end up being 'wild' people in the street. Nozomu's students brings various wild people to his house and ask him to take care of them. Nozomu flatly refuses the offer, but he cannot help but to take care of them. Unfortunately, Nozomu is fired from his school for his suspicious conduct and he himself becomes a 'wild' teacher. In the second part of the episode, Meru Otonashi's dad wants to find a suitable voice actor for her as she has inferiority complex of her voice. However, no one seems to have a voice that matches with Meru's character. After the failed audition, she goes throught a number of troubles thanks to the voice transmitter attached to her neck. In the third part of the episode, Nozomu complains that people seem to have too many statements on the premise of something as it is a serious breach of etiquette. While Nozomu makes a visit of a Tsundere cafe in Akihabara, he finds numerous instances where unnecessary premises are made. Moreover, Nozomu confronts an enemy character, but they end up being friends together on the premise that the anime series is indeed derived from a Shōnen manga.

Nozomu is paying a visit to Chiri's house after going through various scenes, but his home visit abruptly ends when he reaches Chiri's house. Chiri argues that Nozomu's visit was pointless, but Nozomu points out that most Japanese people take the process more seriously rather than its result. As a typical shōnen manga puts emphasis on the character's development throughout the story, Nozomu asks his students to appeal the audience by showing off development of their immaturity. In the second part of the episode, a warning of earthquake disaster is published by the Ministry of Prediction, which makes every characters except Chiri very lazy as they believe they are not going to make appearance in the magazine. Meanwhile Nozomu points that many Japanese put efforts into various activities despite being aware there won't be any reward for their action. A number of Nozomu's students ends up doing improper conducts as they don't expect themselves to appear in front of the audience. In the third part of the episode, the students are worrying about the dropping interest of book-reading among students. Nozomu thinks that many books should change their titles so that they accurately reflect the content of the book as many books betray the readers' trusts by having inaccurate title. Thus, Nozomu asks Kino and Kudo to give more appropriate names for various books by holding a book-titling competition.

In a Book of Folktales, it shows how Nozomu, first a positive, normal person as a student, is forced to become the negative man he is today.

While watching a baseball match, Nozomu wonders about the sad fate of the multi-talented people. If a famous baseball player is as handsome as a model, is he missing a more successful career? Later on, as Kiri is taking some medicine to treat her cold, Nozomu explain to Majiru why did it took a moment for the medicine to take effect : the dreaded time lag, which can be observed in a lot of phenomenon. As the journey to find themselves continues, more of Nozomu's students embarks on the bus and procede to reveal some parts of their personality. In the end, Kafuka leads the group to expose themselves to reality and at the same time the acceptance of their true self as they are, after which she concludes by singing a heartwarming song.

As Nozomu and Kafuka attempt to find the switch to the town christmas lights, Nami finds she keep switching on other people's switches. Next, Nozomu contemplates on how people making a decision between two things subconsciously end up picking a third. He and the girls end up in a third-choice city. Whilst arguing about excessive care, Nozumu is taken by Rin to a Guardian's Club, where people take excessive care measures.

Since there's an outbreak of measles in town, Abiru suggests to Majiru that he should get infected right now, for it is quite worse to get them as an adult. Nozomu then proceeds to unveils many more types of "measles" you're better off to have as a kid, since their effects can be disastrous later on in your life. As Nozomu and Kafuka walks in the street, they stumble on Kanako Ōra, a laid back and careless girl from Nozomu's class, who doesn't seem to mind that a myriads of political parties uses her property's wall for their posters. As Kafuka and Nozomu continues to explore the concept of "through life", Chiri decide to label object and people so as to know who's the creator.

During a walk, Nozomu gets deceived by Maruuchi Shoko and Nedu Miko, who sell him maguro and a block of ice for 15.500 ¥. Nozomu complains that many dealers make up money only after the customers buy the goods, using tricks. The too mild winder is caused by Shogun Frost who refuses to do his work anymore. The class helps him to find a new job. The class prepares a surprise party for Nozomu, even if his birthday is not on that day, but on 4th of November.

Whilst waiting for the bus, Nozomu and Chiri talks about how important are emergency measures in one's life. Later, at school, the class finds out Nami's birthday, but, because nobody knew about it, everyone makes her a sudden emergency present. Nozoumu, correcting some tests, shows the class how, in the adults' world, there are correct but not right answers. While the class is playing golf, Nozomu's sister tells them that a new course has been created in town. In this new kind of game the balls are represented by people and the tees are disguised as objects or places they have to keep away from as long and as far as they can.

It's Valentine's Day and Kagerou is afraid to open his box, because he doesn't really know whether any girl had dedicated a love letter to him or had not. Nozomu tells hit not to open it, in order to create a Schrodinger's box, in which the possibilities of the presence of any letter and the possibilities of absence are both infinite. A missile drops on the school's field and the class tries despairingly to hide it. An interviewer is, in fact, going to come to the school. After purchasing all the houses and getting the ramen shop Rin notices how the flavour has changed because of changing of her new management.

When Chiri hangs up a painting upside down without noticing, the class are taken through a gallery where involving big mistakes that go unnoticed compared to the minor details. In the second part, Nozomu accidentally causes Kiri's blanket to fly away, and the class go on a search for it. However, it flies onto a government member who decides to mass produce it so people will feel more secure. Soon everyone decides to become civil servants and the world becomes impoverished. In the third part, Nozomu and company discuss buzzword generals and are disturbed by one. Maria then mentions "Kiyohiko's Night" (a mispronunciation of Silent Night) and a Kiyohiko shows up, but is unprepared for the abrupt pun.

The gang encounter several groups of protestors, who protest about things, but end up vaccilating over certain things. Nozomu soons winds up in the same scenario when he comments on the earliness of his gag. Maria shows him a tepid vaccilation, where her cuteness gets her out of several troubles, including extinguishing the Olympic Torch. In the second part, the gang discuss matters where you're compelled to say something is interesting or funny. Matoi decides they should use these tactics to get more laughs from the low minded viewers by using complicated word gags. However, they get attacked by Chiri when she doesn't get the desired response from her dialogue. The third part introduces us to Tane Kitsu, Chiri's older sister who, as a polar opposite to Chiri, constantly makes everything messy. Harumi explains to Nozomu that Tane became messy to stop Chiri from cleaning a goldfish with shampoo when they were little. Nozomu uses this knowledge to control Chiri, whilst Tane falls for him.

The class is learning how to properly use the AED, but Nozomu tells that the Dysfunctional AED (DAED) is the one which everyone should avert. The DAED, in fact, has the task to revive dead things which should remain dead. Ohkusa, anyway, decides to pursue her instincts and starts reviving everything she faces, until resurrecting the deads as zombies. The class, fleeing from the horde of zombies, gets trapped in a store, but Nozomu anyway has been bitten. In the second part the whole class is at the pool and gets washed away to the Island of Those Who Don't Go with the Flow. In the third part Nozomu talks about Doublespeak, in other way the act of disguising words with softer ones.