When the FBI takes on a case of disappearing college girls, Jack Crawford recruits Will Graham, a gifted criminal profiler with a unique view into the psyche of serial killers, to consult. Jack also seeks the help of Dr. Hannibal Lecter, a brilliant psychiatrist. After a copycat strikes, Will and Hannibal join forces to track down the culprit.

Abigail Hobbs comes out of her coma with new information about her father.

Will, Jack and the BAU team hunt for a serial killer who creates a totem pole out of his victims' bodies.