A village is tormented by a Yoma, which is a demon that has disguised itself as a human it has eaten. As a last resort the Chief of the village has ask for the help from a Claymore, who are feared as they are half human, half Yoma. Raki is a young boy who has found an interest in the Claymore and he begins to follow her about until later when he discovers who the Yoma is.

Rabona the Holy City that does not allow the entry of unnatural beings is being preyed upon by a Yoma and as a last resort, have to disobey their own laws and called for help. So Claire now has a job to do but it will be different from the usual Yoma hunting, it's more of a covert operation and she has to suppress her powers to do so. During her searches Claire happens to run into 2 soldiers on patrol, but they only seem to get in the way of her job. After she manages to lose them, Claire faces the Yoma which happens to be an extremely strong one known as "Voracious Eater".

Another Claymore known as Teresa has appeared in a town where she quickly dispatches a Yoma, with no effort. She is well-known as for her nickname "Teresa of the Faint Smile" because she never releases her Yoma powers. In the town of Teo, as soon as she arrives there she ruthlessly attacks any Yoma she senses and after the massacre a girl with no name who was with one of the Yoma seems to be very attached to Teresa. This girl ends up following Teresa no matter what she did.

Two more Claymores have appeared, Sophia and Noel who have entered a town that has become a Yoma hive, don't require much effort to eradicate the hordes of Yoma. There are still some Yoma left but that is until Irene nicknamed, "Flash Sword Irene" finishes them off. Following Teresa's betrayal, the number 2-5 Claymores have gathered with orders to execute Teresa, but who is the remaining Claymore yet to arrive? The ultimate battle between Claymores is about to begin.

Three Claymores arrive in the town of Toriro to only find Claire, who has already taken care of the Yomas. It is revealed that what Claire defeated in the Holy City was not a Voracious Eater but a regular Yoma; because Voracious Eater is a public term for what the organization labels an "Awakened One". Claire has been added to the expedition team to hunt an Awakened One, as a chance to measure the limits of her skills. How will Claire ranked no. 47, fair against such a powerful being after a shocking turn of events?

By working together, Miria and Claire were able to defeat the Male Awakened One, which surprised the handler observing the battle but the team are left with injuries all over the place. In the meantime while they recover from their injuries, they begin talking about their past and it seems like they all have something in common that led to them being teamed up together. It is revealed that they have all experienced the Awakening process in the past.

Claire has separated from Raki in order to save him from the merciless Ophelia, who is currently pursuing Claire. It doesn't take long for Ophelia to catch up with Claire, where she is forced to fight for her life. With Claire putting up a good fight, Ophelia gets excited and decides to reveal the secret behind the name she gave herself "Ophelia of the Ripples". Claire is now in a dire situation, yet there was no chance of winning to begin with, when suddenly a familiar face appears from the shadows.

The Organization is getting uneasy of no. 47 Claire, after receiving no contact from her for three months. Following recent events, they end up taking drastic measures by sending out a Claymore on the mission to find Claire and it's made top priority. Meanwhile Claire is searching for Raki but while doing this a Claymore expedition team pass through the town, to hunt down an Awakened One; in the mountains nonetheless something seems odd about the situation.

Claire has joined the hunt for the Awakened One, in the mountains of Zakol, to save the no. 9 "Jeane". Things seem odd to begin with, as Claire enters the eerie lair, with an irregular Yoki flowing everywhere and the fight begins once she finds the source of the Yoki. Even with the Flash Sword it appears impossible for Claire to defeat her foe however the tables turn with the arrival of no. 3 "Galatea". More is revealed about the powerful Awakened One in the mountains and the reason why it's gathering more Awakened beings.

Awakened Beings have launched a surprise attack on the city of Pieta, forcing the teams of Claymores to begin their battles against these unbeatable creatures. Even with these incredibly powerful Awakened Beings to fight against there may be some Claymores who are able to handle this sort of situation, which will only get tougher in the future.

Having just heard the news of what happened in the City of Pieta, Isley has ordered his entire army of 27 Awakened beings to annihilate the Claymores located there. With the probability of this mission ending in success zero, no matter the odds the teams of Claymores are still determined to carve out their path of survival. Meanwhile Raki is heading towards Pieta with Isley and Priscilla when he later discovers something shocking.

The fight rages on and while battling with the unbeatable Rigardo, Claire has inadvertently awakened partially and dealt a deadly blow. With her new found abilities Claire has proven herself to be a great adversary for the "The Silver-Eyed Lion King", so now he is finally able to go all-out.

In the middle of an active volcano, Claire and Priscilla are finally going to face-off and even in her partially Awakened form Claire is still not any closer to being a match for former no. 2 Priscilla. For whose sake is Claire willing to risk her life for? Just when Priscilla was about to finish things Miria, Helen and Deneve arrive just in the nick of time, although what can they do against this formidable foe, who hasn't even shown her latent power.

The battle between the two awesome powers Claire and Priscilla reaches its climax as Claire somehow manages to gather the strength and determination to go on. Raki and Jeane have also arrived to witness the bloodbath that is about to begin, yet what will be the overall outcome of this battle?