11 year old Chyna starts her first day at High School as part of the Advanced Natural Talents (ANT) Program. There she meets Olive (who is smart) and Fletcher (who is a good artist and has a crush on Chyna). Chyna's two new friends help her learn the ropes of her new school. But, Chyna of course doesn't fit in. So, she decides to sneak into a party and show the High Schoolers what shes got. But, Olive, Fletcher and Cameron (Chyna's brother) might ruin her chances.

Chyna, Fletcher and Olive all participate in the science fair.

After being denied an entrance to a school dance, Olive tricks Chyna into running for student council, Angus then tells her that to run for A.N.T. rep you need to participate in every school activity and Olive was the runner up. So Chyna tricks Olive into running too. Meanwhile, Fletcher feels ignored from China so then Angus then tells him in order to get a girl to like you you first need to relate with their dad. Fletcher then befriends Chyna's dad to see if he has a possibility with China but Cameron gets jealous. At the end, Cameron beats Chyna and Olive for student council and Chyna's dad starts hanging out with Cameron again

After Darryl gets Chyna a bag from the evidence locker at the police station and finds a new designer bag inside it, he accuses her of shoplifting and sends a police officer undercover. When Chyna, Fletcher, and Olive find out that "Charlie Brown" is a cop and that he is spying on them, they pretend that they are robbing a house.

Chyna falls for a new student in the A.N.T. Program from England. He's another artistic genius who goes to school as a robot. But when Chyna tries to ask him out, he asks for advice from Fletcher. Chyna tells Fletcher there's a artistic guy that she is secretly in love with, and if she should ask him out. and Fletcher thinks she is thinking about him. But when he finds out that Chyna and the new kid from England are going out, Fletcher gets help from Angus to sabotage the date. Meanwhile, Darryl challenges Olive and Cameron at the arcade to see who can get the highest score on a game, Donkey King.

Olive becomes a history teacher.

It’s Halloween at Webster High School and it’s Chyna Parks’ first day in the Mutant Program, where monsters go to school with normal high school students. Chyna is Medusa so she fits right in with her new Mutant Program friends: Olive, a mad scientist, Fletcher, a vampire and Angus, a zombie. However, Lexi and the normal kids are terrified of the mutants, so Gibson pairs everybody off to help prepare for the Halloween dance.

Chyna and Lexi both get picked as finalists for the reality show "America Needs Talent" and they end up having to pretend to be best friends.

Chyna, Olive and Fletcher make toys for kids at an orphanage, but then learn that Principal Skidmore is actually selling the toys for profit. Meanwhile, Lexi and Paisley are hired by a mall gift-wrapping

Chyna lands the lead in the school musical, but jealous Lexi tries to sabotage the show. Meanwhile, Cameron learns that a teacher is living at school and offers to rent his family's living room to the man.

Violet, a sports prodigy with slight anger issues, joins the A.N.T. Program. Violet is not afraid of the older kids, including Lexi, who orders Chyna to keep the girl far away from her. Meanwhile, some of the older students take a drivers-education class.

Olive is shocked to discover that her pet robot, Hegel, is no longer functioning and has suspicious screwdriver scratches on his back. When a screwdriver is found in Chyna's locker, Chyna suspects that she has been framed and vows to find the real culprit. In the end, it is revealed that Chyna accidentally overfed Hegel.

A teen movie sensation Sequoia Jones who is playing the role of a tween musical prodigy and follows Chyna around to study for her role. But then, Chyna learns Sequoia is trying to steal her life.

A baby named Sebastian, thought to be a prodigy, is left in the care of the A.N.T.s and Chyna, Olive, Violet, and Fletcher try to uncover the baby's prodigal aptitude. They try art, music, karate, etc. Skidmore entrusts them to find its talent. But actually this was a trick Skidmore played on the ANTs.

Chyna accidentally convinces her father, Darryl, to quit his job after he tells her much he hates it. Darryl tries finding other suitable jobs, but it is no use. Chyna does not like seeing him depressed, so after she witnesses him track down the remote control very cleverly, she tells him to work as a private investigator. Plus, Chyna creates a fake crime scene at school to get his business started. Meanwhile, Lexi is horrified when she realizes that she and Paisley have the same amount of friends on Wolf Pack, a popular social network. After finding out that Cameron just signed up to Wolf Pack, they try to compete over whose friend request he should accept first in order to obtain more friends.

Chyna and the ANTs are tasked with creating a special project for Black History Month. As Chyna struggles to write a song for her presentation, she decides to lock herself in a recording booth until she comes up with a great song. After accidentally falling asleep, Chyna takes a dream journey back in time where she becomes famous African American music icons from the past, Ella Fitzgerald, Aretha Franklin, and Janet Jackson. Using her dream as inspiration, Chyna writes a new version of the A.N.T. Farm theme song "Exceptional" with lyrics that pay tribute to the great women who came before her.

Chyna, Olive, Fletcher, Angus and Lexi audition for an exclusive school.