Tarzan and Jane return from a trip to the Waziri village to find the Professor missing and his camp in ruin. Jane momentarily fears the worst, but soldiers on with Tarzan in an attempt to determine her father's whereabouts and condition—a pursuit impeded by the hordes of apparently mad animals, including Terk and Tantor, destroying everything in their path and pleading for the cessation of a mysterious, unheard ringing.

A logger's daughter and workers fall ill with a dangerous disease. Tarzan seeks to obtain a cure for the disease, only to find out the cure may have been destroyed by their irresponsible logging.

A film crew arrives in the jungle to shoot an action movie. Tarzan, being unaware of this, interferes in the process, causing him to appear in the scenes unintentionally. The film's male lead actor becomes jealous after being replaced by Tarzan and attempts to destroy the footage, causing a huge fire at the trading post.

Hugo and Hooft use Tarzan to help them gather special ingredients for their hot sauce. The sauce, with the guys' names on the bottle, becomes popular to the French Foreign Legion, and is brought to the attention of Lt. Col. Staquait. Staquait vows to re-capture Hugo and Hooft for deserting, and succeeds eventually, resulting in the duo being sent to the Cape Doom prison. Upon attempting to free his friends, Tarzan is also captured. Jane attempts to contact the Magistrate to free Hugo and Hooft legally.

Clayton's sister kidnaps Jane, Tantor, Terk, and the Professor, placing each in a separate, deadly peril. She then injects Tarzan with a fatal poison via blowdart and informs him that the antidote lies far away on a distant mountain she's dubbed "Clayton's Peak". He, therefore, has a choice—to suffer as she had and lose those he loves, or as Clayton had and lose his own life.

A writer named Ed is in desperate need of some inspiration for his next novel. He finds it while walking down the street in the form of a newspaper article about Tarzan, "The Missing Link". He begins tracking down various leads to Tarzan's whereabouts, including Tarzan's friends and enemies. They all tell Ed of their first encounters with Tarzan, prompting Ed to head out into the jungle to find Tarzan himself.