When ghosts wreck a popular co-ed's school social life, she dedicates herself to hunting them, which forces Danny to deal with a threat just a few lockers down the hall. Worse yet, Tucker has a crush on the girl.

Danny and Sam find their platonic friendship turned forcibly romantic through the musical powers of Ember, a hard-rocking girl ghost who feeds off the idol worship of teens. With her massive, free concert scheduled only a few days away a concert that will be broadcast worldwide and give her ultimate power Sam has to get the now completely and utterly love-addled Danny to focus on fighting ghosts. Even if it means breaking his heart.

When Jazz falls for hunky boy ghost, Johnny 13, who can cast his shadow out and create bad luck for everyone who crosses him - especially the girls he's dating, Danny is forced to behave like an overprotective parent, much to Jazz's dismay.

Amity Park is thrown into chaos by the town's first mass invasion of ghosts. It's all part of a plan by the Ghost Zone's top Sheriff, Walker, to capture Danny Phantom. As Danny first battles, then befriends, a hulking ghost named Wulf, Walker and his deputies ""overshadow"" most of the people in Danny's inner circle. While eluding attacks from his ghost-fighting parents, Danny defeats Walker and restores calm in the city - but earns the title of ""Public Ghost Enemy #1"" in the process!

When Paulina witnesses Danny's ghost transformation, he fears the exposure. Imagine his surprise when Paulina swears to keep his secret - then becomes his girlfriend! Life is great for Danny, until he finds out that Paulina has actually been overshadowed by Johnny 13's girlfriend, Kitty, in her plot to make Johnny jealous. Danny reluctantly plays along to protect his own identity, but, when Kitty's welcome wears thin, Danny pleads with Johnny 13 to take her back. When Kitty abandons Paulina's body and goes back to her true love, Paulina resumes her indifference towards Danny Fenton - although she's now madly in love with Danny Phantom!

After being bitten by tiny green ghost beetles, the kids of Casper High get a mysterious illness that gives them ghost powers and are quarantined at a spooky old hospital outside of town. When Danny sneaks into the hospital to investigate, he is captured by Penelope Spectra and her assistant, Bertrand. They are the ones who started this illness as part of their plan to build Penelope a young and beautiful new body. All she needs is Danny's half-human/half-ghost DNA to complete her ghostly plan. With Danny captured and Sam sick, it's up to Tucker to conquer his fear of hospitals and free Danny before Penelope gets what she's after.

After an argument with their respective boyfriends, Spectra, Kitty and Ember join forces and use their powers to make all men vanish. Danny and Jack are fishing in Lake Eerie, the only place on Earth immune to the spell. Sam, Jazz and Maddie must stop the villainesses while Danny is out of town. Unfortuantely for Danny, Skulker is taking more time hunting Danny to prove his girlfriend how great hunter he is. Can Amity Park be saved without its hero?