Gia, a grieving writer, decides to write a book about women's desire. At the center is Lina, a housewife in Indiana; Slaoane, a glamorous entrepreneur in the Northeast and Maggie, a waitress in North Dakota.

Lina flees from a stagnant marriage and a body of pain; she joins a women's group at Doctor Henry's, tries to reconnect with the love of her life, and begins a friendship with Gia.

A difficult visit from her mother propels Sloane further toward Will; Richard attempts to appease Sloane's desire in a different, ill-fated way.

Maggie summons the courage to tell her parents and the police about the relationship with her high school teacher that has been affecting her life ever since.

Jumping back in time, Gia struggles to write her book about sex in America; embarking on a love story of her own, Gia processes the pain of her own losses; she moves to Indiana and bonds with Lina.

Lina, Sloane, and Maggie connect with their hearts' desire, unaware of the fallout that awaits them.

In Indiana, Gia and Lina's bond is threatened by the sudden arrival of Jack and the telling of a long-held truth.

When Aaron Knodel is put on trial, Maggie is forced to accept a huge loss.

Sloane hatches a secret plan to get everything she wants, culminating in an evening filled with intimacy and revealed secrets.