Desi and Cata discover the corpse of a woman inside the mansion they just cleaned. Terrified, they run away from some Russian hitmen and realize they accidentally took a bag full of money with them.

Desi and Cata try to return the money to the Russians, but they want something more: their heads. Desperate, they ask Irene for help, the cop on the case, who’s also Desi’s ex-girlfriend.

Irene can’t help the ladies due to her history with Desi, so Cata decides to go back to Mexico with Ubaldo. But the cop traced their tracks, so escaping the country becomes mission impossible.

The ladies decide to interrogate Eduardo Roselló, but everything goes south when the police discovers that Irene has been helping the suspects... and also when the Russians find Cata and Desi again.

Desi, Cata and Irene, together once more, have to prove that Eduardo Roselló killed his sister. But Eduardo has his own plans to blackmail Néstor and pin the murder on him.

Néstor is now the main suspect, so Desi and Cata ask Eduardo for his help to prove it. Irene gets an ultimatum from her boss: either she hands the ladies in or she’ll be kicked off the force.

Under the relentless desert sun of Alicante, Desi and Cata come face to face with Néstor and Eduardo in a thrilling final duel in the middle of a wild western town.