After suffering a heart attack, Andy tells a young pregnant woman that in order to save her and her unborn child she must get a heart transplant. However, unexpected complications with the donor's family place the transplant in jeopardy.

Claiming he has turned his life around, Andy (Alex O'Loughlin) convinces UNOS to give a former drug addict names Scott (Shiloh Fernandez) a new heart.

Following a bus crash, the parents of a football player must make a heartbreaking decision whether to donate his organs. Meanwhile, Andy and Ryan rush to find a procurement team to give a boy a heart transplant he desperately needs.

In order to save his life, Andy tries a risky new procedure on his wife's partner who suffers from an aortic aneurysm.

Lisa becomes very attached to an 8-year-old boy who she witnesses being crushed by a ride at a fair. Meanwhile, Andy and David try to get a VAD (ventricular assist device) for one of their patients.

Andy and Sophia treat a car crash victim named Victor dying from ALS who asks to be to taken off of life support so his organs can be used to save others. Meanwhile, David tends to a foster parent with pulmonary hypertension who refuses admission to the hospital.

The wife of a billionaire suffers the consequences after a setback leaves her without a new liver and her husband resorts to buying one on the black market. Meanwhile, a friend from Andy's past resurfaces.

When a woman's husband needs a new kidney, she contemplates beginning a "Daisy Chain"; which means she will donate a kidney to someone and they in turn will donate their kidney until the chain is completed with her husband getting his kidney. Andy is not sure he wants to support such an action and he is concerned that another patient is rejecting his recently transplanted heart.

A firefighter must decide whether to be a living donor to her captain, a man who has mistreated her. Meanwhile, Andy's uncle turns up with a stab wound and asks him not to report the incident for fear it will violate his parole.

When Dr. Luc Bovell returns to Three Rivers, Andy is annoyed at his rival's status and popularity since he is rude to his patients.

An plane accident leaves a Korean woman blind, requiring a cornea transplant. A woman discovers that she is not pregnant and, instead, suffers from Ascitis. Miranda does everything to save her. Andy is bothered with Luke for trying to experiment with one of his patients.

Andy puts his patient Kuol at the top of the donor list to receive a new heart after his condition takes a turn for the worse. His transplant is put in jeopardy when police threaten to seize the money raised for Kuol's surgery.