Despite several team members having grave reservations, NCIS travels to Mexico for a risky mission to locate and rescue Mosley's son.

Gravely injured and unable to communicate with the team in the U.S., Callen, Sam and Kensi, with an unconscious Deeks in tow, search for a safe way home as a cartel boss places a “dead or alive” bounty on their heads. Also, Mosely and retired Navy Admiral Hollace Kilbride beseech their contacts in Mexico and D.C. for assistance with their missing colleagues

The NCIS team attempts to locate Mosley after she murders a cartel hitman and goes off the grid.

Deputy Director Ochoa volunteers the NCIS team to assist with a covert operation tied to a terrorist group advocating for extreme military force. Also, Callen has concerns as to what an assignment of this nature could mean for the future of the team.

The NCIS team works with the Global Criminal Tribunal when a Syrian seeking justice, David Sarraf, is brutally attacked while delivering evidence that would prove chemical weapons were used on civilians. Also, Kensi stays at the crime scene and comforts Sarraf who is pinned behind a vehicle.