Daisy has left S.H.I.E.L.D. and is trying to solve the mystery of a bunch of serial killings in the Los Angeles area. At the same time her old friends suspect her for the killings and are following her trail in an attempt to find her.

As Robbie Reyes struggles to control the Ghost Rider; S.H.I.E.L.D. infiltrates a high-security prison to unravel the secrets that haunt them all.

Daisy, Director Mace and the S.H.I.E.L.D. team must find a way to contain an explosive Inhuman. Meanwhile, Coulson and Mack come face-to-face with Radcliffe’s inspiration for Aida.

Suspicion turns to paranoia when the team doesn't know who can be trusted as more LMDs infiltrate S.H.I.E.L.D.

The clock is ticking for Daisy and Simmons to get the team out of the Framework, but not everyone is ready and willing to leave.

Coulson and the team's victory in the Framework is short-lived, as an even deadlier enemy looms against them all.