When Daisy gets a horrifying glimpse of the future, S.H.I.E.L.D. races to prove that fate is not fixed.

S.H.I.E.L.D. hunts for information on their dangerous new enemy, and a shameful secret from Malick's past is exposed, threatening to destroy his HYDRA legacy.

The S.H.I.E.L.D. team is left reeling and decimated as Hive continues to sway Inhumans to his side. But there is a sliver of hope as Agents Fitz and Simmons follow a lead that may be able to stop the maniacal Inhuman once and for all.

Coulson and his team race to combat Hive's control over the Inhumans, as their enemy's deadly plan for the human race is revealed.

As Coulson, Mack and Fitz attempt to track down and neutralize a rogue group looking to end Inhuman Registration worldwide, Simmons and Dr. Radcliffe only have hours to save May before she succumbs forever to her mysterious illness.

With the loss of half the team, the remaining members search for answers as the clock counts down for Ghost Rider.