Coulson and his team are now wanted fugitives with limited resources, but that's not stopping them from keeping the world safe from powerful and unseen threats everywhere. However, with new members they hardly know, will S.H.I.E.L.D. ever be trusted again?

Coulson and his team are still reeling from a shocking revelation that leaves the team fractured as they must decide what to do with one of their own. Meanwhile, Bobbi and Mack reveal their true allegiance to Hunter, while elsewhere, Ward and Agent 33 embark on a personal mission.

Coulson and General Talbot are forced to team up and attend a worldwide symposium on Inhumans, where they suspect Malick has an inside man. As the S.H.I.E.L.D. team gets closer to the truth, an unexpected traitor is revealed.

Coulson uncovers General Hale's true agenda, and it could be the end of the world if S.H.I.E.L.D. doesn't help her.

While an agent's life hangs in the balance, Fitz, Simmons, and Yo-Yo attempt to neutralize a weapon that could play a role in Earth’s destruction.

Daisy's future as the Destroyer of Worlds could take a critical change.