When the brilliant scientist, Dr. Franklin Hall, is kidnapped, Agent Coulson and his S.H.I.E.L.D. agents must race against the clock to locate him. Skye is their only way in–pushing the team to their limits when the entire plan turns upside-down.

With Colonel Glenn Talbot now on their trail, Coulson and his team seek refuge in the last place anyone would look, where they begin to uncover S.H.I.E.L.D.'s most dangerous secrets. Secrets that could destroy them all.

Coulson and team find themselves in an epic face-off against HYDRA to uncover an ancient secret, while Ward kidnaps his brother, Senator Christian Ward, for a violent trip down memory lane.