While tracking a young boy with dangerous powers, Dr. Helen Magnus encounters Will Zimmerman, a psychiatric resident who may have what it takes to become her new protégé.

Will Zimmerman is drawn further into Magnus' mysterious world and finds himself confronting his oldest fear. Elsewhere, forces converge on the target of their hunt - including someone from Magnus' distant past.

The origins of the mysterious mutant boy are revealed, as is the relationship between Magnus and her old flame, John Druitt. Meanwhile Ashley Magnus (Emilie Ullerup) seeks out Ernie Watts (Peter Deluise) a weapons dealer and fellow monster hunter - only to find herself in mortal danger.

Helen and Will confront John Druitt with deadly results for a member of the Sanctuary team. Ultimately, Will is forced to choose between his old life and the strange world of Dr. Helen Magnus.

While investigating an ancient crypt on a remote island, Magnus and her team encounter deadly creatures and three women with a mysterious past. Ashley decides to address the issues of her father's existence head-on.

The investigation into the three women found in the crypt continues, confirming Magnus' theory that they are much more than they appear. Ashley's hunt for contraband creatures yields mixed results.

Will falls victim to the three women's growing powers, while Magnus seeks proof of their true identities via a former resident of the Sanctuary. Ashley's luck in her monster hunt begins to run out.

Magnus, Will and Bigfoot defend the Sanctuary against a deadly assault, while Ashley struggles to survive her encounter with a nearly unbeatable foe.

The enigmatic Dr. Helen Magnus recruits insightful forensic psychiatrist Will Zimmerman to join her in the quest to track, study and protect the strange and often terrifying creatures that secretly populate our world.

As Will attempts to help Alexi cope with his abnormality, Helen gets a visitor from her past.

Dr. Helen Magnus, her daughter Ashley, and new to the Sanctuary, Dr. Will Zimmerman release three women from a mysterious crypt in Scotland, bringing them back to the Sanctuary for refuge. Unbeknown to the team, and the women themselves, they have extraordinary powers. And their disappearance does not go undetected by a powerful cabal, resolute on reclaiming what it determines is theirs.

An investigation into a string of bizarre robberies leads Magnus and Will to a crime ring of thieves who seem to be able to slip between the cracks of the law… literally.

After capturing a particularly elusive abnormal the plane carrying Dr. Magnus and Will crashes while transporting the creature. Dr. Magnus and Will soon discover why this abnormal has never been captured before.

When a mating pair of cute, furry and seemingly harmless abnormals is brought in for scientific study, the Sanctuary team begins to exhibit some hidden animal attractions for one another.

While leading a covert meeting in Rome, Magnus encounters an old friend from her past who confides that the cabal has come to exact revenge on her for the events in "Fata Morgana."

A young artist with an uncanny ability to draw remarkably detailed pictures from memory may be the key to solving a case surrounding the suspicious death of his abusive father.

Magnus and Will investigate a distressing call for help deep below the Bermuda Triangle resulting in a deadly battle to save Magnus’s life.

Investigating the disappearance of an old college friend, Will finds himself caught in an underground fight club where the combatants are genetically engineered abnormals who fight to the death like modern day gladiators.

Magnus and the Sanctuary team attempt to capture a rare and deadly creature - all under the watchful eye of a local news crew.

Abnormals in remote regions are subjected to an airborne biological agent that compels them to launch a violent string of murders

The Five, led by Magnus, attempt to find the secret labyrinth in the decimated city of Bhalasaam. Once located, they must complete a series of cryptic tests that can only be achieved using each of their unique powers.

The search for Ashley puts Magnus and her allies in the path of Kate Freelander (Agam Darshi), a con artist with ties to the Cabal who divulges the location of a secret facility

The Cabal's new "Super-Abnormals" begin destroying Sanctuaries around the world. It won't be long before they launch their attack on the Old City Sanctuary, and Magnus must choose between saving Ashley and saving the Sanctuary Network.

The team rescues the occupants of a sinking ship off the coast of South Africa and teleport them to the Sanctuary. However, Magnus suspects Druitt of murdering one of the passengers during the rescue.

The team investigate a murder in Mumbai, and find a connection to the ancient cult of Kali, whose followers can foretell disaster. However, Will falls ill and disappears, and is somehow linked to the mystery.

Will begins to experience strange visions that are connected to the Cult of Kali. Magnus has difficulty with finding the solution to their problems.