A young artist with an uncanny ability to draw remarkably detailed pictures from memory may be the key to solving a case surrounding the suspicious death of his abusive father.

Investigating the disappearance of an old college friend, Will finds himself caught in an underground fight club where the combatants are genetically engineered abnormals who fight to the death like modern day gladiators.

With chaos all around them, the team must come to terms with how to rebuild after the Cabal’s attacks. Magnus takes a methodical approach to prove Ashley is still alive, while Will and Henry take on the daunting task of processing the hundreds of Abnormals who now seek refuge at the Sanctuary.

A disoriented Magnus wakes up to find the Sanctuary in ruins and the entire city decimated, with no memory of how the devastation occurred. While surveying the destruction, she is attacked by an inhuman creature but saved by two armed men who stun her and take her to an abandoned warehouse. After being hosed down and left shivering and exhausted, Magnus fears the worst when a battle-scarred figure enters the room.

While an old friend of Magnus', a pouched abnormal named Jimmy, is handing over a fire elemental to the Sanctuary team, they are attacked by a gang of criminal abnormals from Chicago. The situation presents a lot of mysteries to be solved and quickly.