NCIS Agents Nick Torres and Jessica Knight travel to Hawai'i when they learn a key witness in one of their old cases has turned up there with crucial evidence.

The crossover starts on NCIS S19E17 Starting Over (I).

When Special Agent Pike is ambushed while working undercover with a local Japanese crime family, the team must find the person responsible for orchestrating the attacks. Also, Kai goes deeper into his investigation regarding an old friend turned criminal.

Captain Milius returns to Hawai’i as the NCIS team works to catch a dangerous high-value U.S. Government target with the help of an informant unlike any they’ve ever encountered. Also, Tennant and Daniel deal with Alex’s acceptance into the Naval Academy

After a Marine's wife is kidnapped for ransom, the NCIS team uncovers dark secrets as they race to track down her abductor before it's too late. Meanwhile, Sam seeks Ernie's expertise decrypting a computer program that may have deadly ramifications.

When a high-value bioweapons expert is murdered in a secure facility on Hawai'i, NCIS and the NCIS Elite team join forces to track down the killer and discover an even deadlier threat.

Following a devastating ambush with a deadly bioweapon, the NCIS team must track down a mysterious terrorist group before they can strike again.