Marco Amoretti, a former Navy Petty Officer from the American Empire, has come to Japan and is committing heinous acts of brutality against women.

Section 9 is assisted in this matter by the American Empire's CIA. While this doesn't sit well with Public Security's members, Batou finds the whole case particularly hard on his psyche as the nightmares from his past rear their ugly head.

Back on the Laughing Man case, Section 9 tries to find evidence of tampering in the Nanao=A case and delves more into the recent hack job at the Ministry of Health, Labour and Welfare ("PORTRAITZ"). Using J.D. Salinger's The Catcher in the Rye as a guide, Togusa checks out the MHLW and finds that something is missing: a ledger containing a list of vaccine recipients.

The Laughing Man returns and, just as he did six years ago, kidnaps the President of Serano Genomics without being detected. Section 9 arrives too late and sets out to find him.

Meanwhile, the Laughing Man and Mr. Serano discuss what happened six years ago. The stakes are much higher this time, and for the Laughing Man failure is not an option.

Training has commenced to find new recruits for Section 9. With Motoko acting as the target, Batou and Togusa watch as the recruits try to keep up with the Major.

After ditching some of the recruits, Motoko has to lose just one more pair. She ascends some stairs in an alley and the recruits follow her. Moving out into the street above, the recruits see that they have lost the target. However, Batou and Togusa have lost contact with the Major as well.

Section 9 heads to Etorofu in search of Kuze. During their investigations, the Major finds an interesting floppy disk on the body of a dead addict.

The floppy proves to be a goldmine of information, as it contains records of plutonium transactions. The last buyer to purchase the material was a group of Asian refugees. Realizing the transaction is about to take place, the team rushes to the location and is surprised by what they find.

As the attack on Dejima escalates, the Major catches up with Kuze. She explains the whole situation to him and he agrees to follow her. They are about to leave when both are attacked by the Self-Defense forces and in the confusion are trapped under the rubble.

Togusa rescues the Prime Minister and brings her back to her office. There, Aramaki hopes her influence will stop the launching of the ultimate weapon. Meanwhile, Batou reasons with Section 4.