Agnese's words have created a rift with Andrea, who must also come to terms with being away from Giulia, who is in Rome for research. Meanwhile, Teresa must work wonders to find a place for Diana's daughter, admitted despite her mother's doubts. Elisabetta is also admitted to the ward after a few days of illness, maybe an indication of a more serious problem.

A violent earthquake sows panic at the Ambrosiano Hospital. Lin is afraid for her family; Ric decides on Laura's proposal; Federico has to perform a surgery for which he does not feel ready; Martina has an encounter that threatens to bring up her secret; Giulia, on the other hand, has to manage the ward because Doc is stuck in an elevator and has to save a pregnant patient.

The deadline to submit the research is approaching, but Giulia seems to have other things on her mind. Even Doc struggles to manage the myriad commitments: there's the meeting with the funders and then there's Carolina, who is in town for a few days. Everything takes a back seat, however, when Lin's sister is hospitalized. A case that will force the resident to come to terms with her father.

Giulia must make a decision about her personal life that will also affect her career. While Martina faces the most difficult exam of her life, Ric takes on a case that will force him to come to terms with Alba's ghost. Lin and Federico, on the other hand, get back to work on the database, but they risk bringing Doc closer to the truth that Agnese has been hiding from him.

Andrea is forced to come to terms with Agnese's illness, but unexpected news from America reawaken his hopes. At the hospital, however, the new head physician is challenged by a case that will force someone to make a terrible compromise. Meanwhile, Lorenzo is entrusted with a patient who has arrived from a nursing home and has been prescribed an overdose of medication.

In the ward, the moment of truth has arrived. As Federico faces his last day at Ambrosiano Hospital and Martina makes a decision that leaves the rest of the team stunned, Doc must come to terms with the truth Agnese has told him. He is convinced that it can't get any worse - until the man responsible for it all, his worst enemy, is admitted.