After reuniting with Gwen Stacy, Brooklyn’s full-time, friendly neighborhood Spider-Man is catapulted across the Multiverse, where he encounters the Spider Society, a team of Spider-People charged with protecting the Multiverse’s very existence. But when the heroes clash on how to handle a new threat, Miles finds himself pitted against the other Spiders and must set out on his own to save those he loves most.

The beautiful world of Gaya is home to two similar humanoid species: Zeldons who are the furry majority residents, and Snurks, who are goblin-like outcasts. But suddenly all Gayans are facing imminent danger when a magic stone which protects their world, "the Dalamite", is beamed away by a mysterious force. Three Snurks immediately go after it, hoping to be the heroes for once. They are shortly followed by some standout Zeldons: Zino the trouble-prone popular guy & his sidekick, clever but somewhat cowardly inventor Boo, as well as rebel princess Alanta. Their journey ends up leading them all on a dangerous interdimensional quest to find the stone, while they must also figure out a way to get back to Gaya.

Taking place right after the events of Spider-Man: Across the Spider-Verse, Gwen Stacy leads the newly reformed Spider-Gang in a race against the Spider-Society, led by Miguel O'Hara, to find Miles Morales, who is trapped in the home dimension of the spider that bit him, along with an alternate version of himself as the Prowler, while the Spot begins his deadly attack in his dimension with far-reaching multiversal consequences.

A young actor's perfect life takes a madcap turn when she agrees to star in a commercial — and suddenly gets transported to her character's world.

11-year-old Frolie moves into the Very Important House and suddenly finds herself in the role of caretaker of the universe.