Múltiplas gerações da família Joestar, todas com a mesma alcunha, defrontam vilões sobrenaturais ao longo de várias épocas.

Johnny Bravo tells the story of a biceps-bulging, karate-chopping free spirit who believes he is a gift from God to the women of the earth. Unfortunately for Johnny, everyone else sees him as a narcissistic Mama's boy with big muscles and even bigger hair. In short, he is the quintessential guy who 'just doesn't get it.' No matter what he does, or where he finds himself, he always winds up being his own worst enemy.