Stef Foster, a dedicated police officer, and her partner Lena Adams, a school vice principal, have built a close-knit, loving family with Stef's biological son from a previous marriage, Brandon, and their adopted twins, Mariana and Jesus. Their lives are disrupted in unexpected ways when Lena meets Callie, a hardened teen with an abusive past who has spent her life in and out of foster homes. Lena and Stef welcome Callie and her brother, Jude, into their home thinking it's just for a few weeks, until a more permanent placement can be found. But life has something else in store for the Fosters.

After losing her parents in a tragic accident, Zhuo Yifeng suppresses her past through selective amnesia and takes on a new identity as Su Nianfeng. Raised by her parents' friend alongside his son, Su Muyun, she struggles with an uneasy sibling-like relationship. As she navigates high school, Su Nianfeng finds inspiration in her close friend Yue Diyin, whose warmth and resilience motivate her to pursue a career in medicine despite his battle with a mysterious illness.

An intimate look at five families who take in children removed from their biological homes by the Director of Youth Protection (DYP). Nancy Audet, a journalist and former child of the DYP, guides us through their complex and often trying daily lives, but filled with resilience, courage and kindness.