Nanotechnology researcher Wang Miao is taken to the Joint Operations Center by police officer Shi Qiang, who's investigating the mysterious suicide wave among scientists worldwide, and recruited to sneak into an organization called the Frontiers of Science to help the investigation. When Wang Miao is contacted by the leader of the organization, Shen Yufei, she introduces him to a sophisticated VR video game called Three-Body, but soon he discovers that it's more than just a game.

He Peijin, a housewife, after quietly contributing to the family for nearly two decades, her husband suddenly filed for divorce on the grounds of cultural gap. In order to save the family, Peijin decided to apply for university as an advanced candidate, but was unanimously opposed by her husband and son. At this time, Peijin was misdiagnosed as having cancer again, and there is not much to come. Peijin decided to live completely for herself in the last time and realize her dream of going to college. After enrolling, Peijin and her son became classmates. Facing a group of classmates with generation gaps, Peijin was marginalized, but she gradually won the love of the "little" classmates with her life wisdom and personality charm.

Can five single, independent career women who live in the Ode to Joy apartment building find fulfillment on their own terms? An Di is a successful business woman who has returned to China after studying in New York to find her younger brother. Qu Xiao Xiao is only 25 but already owns her own small business. Fang Sheng Mei grew up in poverty but has shed her “Princess of the Streets” background to work for a multinational company. Qiu Ying Ying is a 20-year-old small-town girl who is trying to make it in the big city. Guan Ju Er is a 20-year-old from a highly educated family, but she must discover what she wants out of life when enters the workforce for the first time. For these women, there is a man (or two) who is trying to get their attention. Dr. Zhao is a flirtatious, handsome doctor. Qi Dian is the stoic businessman. Wang Bai Chuan is Sheng Mei’s steadfast friend who has always carried a torch for her. Yao Bin is a second-generation chaebol. Tan Zong Ming is An Di’s boss who has been friend-zoned by her despite knowing her since their schooldays.