出雲風子是一位擁有「不運」能力的女孩，但凡接觸她的人都會遭遇不幸。當風子試圖自殺時，一個擁有不朽之身、永不死亡的「不死者」突然出現在她面前，他慶幸自己終於遇到了有能力讓他真正死亡的人。他綁架了風子，並尋找能夠造成最大不幸的條件，但反不明現象控制組織（又名「聯盟」）的捕獵者找上了他們！

三天后，一名UNION成員將前往俄羅斯調查UMA。安迪和風子得知只要殺死該成員，他們就可以進入UNION，於是二人出發前往貝加爾湖。兩人逃過UNION的追捕，抵達貝加爾湖，但因安迪有事在身，他們剛到達目的地就分道揚鑣。風子遇到一個穿着貌似日本女學生製服的女孩。她在開心地畫水彩畫。在她的敦促下，風子決定和她一起作畫......

和風子一起在貝加爾湖作畫的女孩，就是當年俘虜安迪的否定者吉娜！安迪尋找機會反擊，試圖弄清楚她到底否定甚麼。結果，他意識到吉娜擁有異能「不變」，是否定物體變化形式的否定者。吉娜認為風子搶走了自己暗戀已久的安迪，心懷妒意的她表現出敵對情緒。吉娜不斷攻擊，風子因而注意到一件事......

安迪和風子被帶去參加圓桌會議，UNION成員正等着他們。在那裏，默示錄交代了新一輪的任務。默示錄是最早被發現的古代遺物，會塞一些強人所難的任務給UNION。UNION成員認為理所當然應該開始執行任務，風子向他們提出質疑並提議做出改變，但領導者朱易絲卻不以為然。

安迪和同伴抵達美國，目的是抓捕UMA斯波爾。在對一具與斯波爾有關的腐屍進行背景調查後，他們發現他來自渴望小鎮。根據前往渴望小鎮的特工報告，毫無疑問，斯波爾及其製造出來的喪屍就在鎮上。他們一到那裏，安迪就在喪屍群中發現一具尚未完全腐爛的喪屍。他試圖向其打聽斯波爾的下落......

斯波爾將渴望小鎮所有居民變成喪屍。太陽花幼稚園的孩子們躲進地下避難所，他們將事件經過以及他們避免成為喪屍的方法告訴風子。與此同時，安迪在地面上與其他喪屍攜手對抗斯波爾。一具喪屍恰巧碰到風子，觸發「不運」。安迪意識到風子的異能同樣也能對付喪屍......

斯波爾轉入第二階段，腐化靠近它的一切，也向逃離它的所有東西發射腐化鐳射。然而，沈開始用他的古代遺物和否定異能進行反抗。斯波爾無法反擊，但即便如此，因為無法直接觸碰斯波爾，戰鬥依然陷入僵局。這類UMA只有提取其體內的「核心」才能完成抓捕，因此需要想辦法徹底抑制斯波爾的異能。

安迪拔出前額的金屬片額頭卡片後，另一個人格會出現，那就是曾經戰無不勝的維克托。儘管斯波爾已被抓捕，但安迪仍以維克托的面貌示人。UNION成員接連向他發起挑戰，要他恢復原狀。然而，維克托的異能在安迪之上，個性咄咄逼人，UNION成員紛紛敗下陣來。風子蓄勢待發，準備把安迪帶回來！

默示錄在十位UNION成員到來之前就已宣讀任務結果。由於第六次任務失敗，默示錄添加了UMA銀河以作懲罰。UNION成員前往地面，目睹了銀河對世界做出的改變。這次，銀河施加的規則讓跨越星系而來的外星人入侵地球。

否定者「不治」確認會在一場黑市拍賣會附近現身，因此安迪和同伴前往拍賣會場。否定者、UMA和UNION未能獲得的古代遺物都在該黑市流通。安迪和風子偽裝成一對已婚夫婦，潛入拍賣會場。聽到周圍的人將否定者和UMA看作商品的言論，風子詢問安迪，對於否定者而言，是加入UNION比較好，還是被賣掉比較好。

The Union and the Negator Hunters have infiltrated the black market auction venue for a new Negator. Andy and Fuko hurry towards the auction item storage, to stop the Negator Hunters who seek revenge against the world.

While Tatiana fights members of the Negator Hunters, she receives a report that Fuko was wounded by Unrepair. Tatiana unleashes her powers in order to save Fuko!

A huge explosion occurs from within the luxury liner sends Andy and company up into the air. They find Rip and company among the rubble. If they let Rip get away, Fuko will die. A roller-coaster ride of a battle ensues.

Fuko and Andy head over to right outside Chikara’s school in order to hear his reply about joining the Union. Rip, who was supposedly dead, suddenly shows up as a young boy. Chikara over hears their conversation...

Apocalypse reads out the quests that have the 100th penalty on the line. However, Billy suddenly declares that it’s impossible for the Union to kill God, and tries to take off with the Roundtable...

To regain the Roundtable, the Union commences an operation with Andy and Fuko as central members. Andy chops his head off while being kissed by Fuko. His head turns into a Parts Bullet and goes into Burn's stomach.

The Union regains control of Apocalypse, but the Roundtable has been seized. Juiz starts telling the members how this world is in a Loop of destruction and reconstruction by the hands of God, and that the Union is an organization she created to thwart such actions.

The possibility has risen that Fuko’s bible in life “To You, From Me” was a manga drawn with an Artifact. Andy and Fuko are tasked with checking the status of the raw manuscripts and gaining intel about Anno Un.

Andy and Fuko await for Anno Un on a bench in Stanley Park. Before they know it, Anno is reading Fuko’s manga and declares that they know what the pair is looking for...

Andy's memories become a book thanks to Autumn's claw that Anno Un materialized. Using the Artifact Soul Caliber, Anno Un plucks out Fuko's soul to send her inside Andy's book. The journey to learn about Andy begins.

Fuko arrives at Victor's memories but is killed by him shortly. Time flies by and Fuko moves on to the final chapter. While Fuko searches Shinjuku for Andy, Victor's blades are unleashed!

Anno Un's true self is Akira Kuno. Young Akira's came across the Artifact, "G-Liner." This Artifact allows the first person to touch it to see the past and future events of the current loop in its entirety. This incident greatly changes his future destiny.

Now that Autumn is stronger, individual attacks are of no use. Anno Un asks Andy and the gang to buy some time to draw the most powerful Artifact necessary in capturing Autumn...