After receiving a cryptic, urgent distress call from Dr. Beverly Crusher, Admiral Jean-Luc Picard enlists help from generations old and new to embark on one final adventure: a daring mission that will change Starfleet, and his old crew forever.

Aided by Seven of Nine and the crew of the U.S.S. Titan, Picard makes a shocking discovery that will alter his life forever – and puts him on a collision course with the most cunning enemy he’s ever encountered. Meanwhile, Raffi races to track a catastrophic weapon – and collides with a familiar ally.

Picard grapples with an explosive, life-altering revelation, while the Titan and her crew try to outmaneuver a relentless Vadic in a lethal game of nautical cat and mouse. Meanwhile, Raffi and Worf uncover a nefarious plot from a vengeful enemy Starfleet has long since forgotten.

With time running out, Picard, Riker and crew must confront the sins of their past and heal fresh wounds, while the Titan, dead in the water, drifts helplessly toward certain destruction within a mysterious space anomaly.

Caught by Starfleet and facing court martial, paranoia grows as Picard struggles to uncover whether a prodigal crewman from his past has returned as an ally – or an enemy hellbent on destroying them all.

Now on the run, Picard and the skeleton crew of the USS Titan must break into Starfleet's most top-secret facility to expose a plot that could destroy the Federation. Picard must turn to the only soul in the galaxy who can help: an old friend.

Vadic forces Picard to make an impossible choice: deliver what he can never give... or watch his crew perish. Their only salvation lies in the mind of an old friend and old foe.

A devastating revelation about Jack alters the course of Picard’s life forever – and uncovers a truth that threatens every soul in the Federation. The final battle begins as Picard and his crew race to save the galaxy from annihilation – but not without a gut-wrenching cost.

In a desperate last stand, Jean-Luc Picard and generations of crews both old and new fight together to save the galaxy from the greatest threat they’ve ever faced as the saga of Star Trek: The Next Generation comes to a thrilling, epic conclusion.