A woman involved in a car accident is concerned about her dog so John agrees to take care it, which complicates his life. At the hospital, doctors treat a girl who has difficulty breathing and a man who appears to be drunk. When a man has chest pains at a party, his guests think he is joking. The paramedics rescue an injured hunter.

John plots his revenge after being the repeated target of practical jokes. A man breaks his back falling off a tower. A woman fakes an illness. Dr. Early's stethoscope becomes lodged in his ear. A man brought into the hospital from a movie set is the first indication of an outbreak of botulism. A boy is trapped in a condemned building.

John delivers a cyanotic baby. The firemen give Roy a bad time about his cooking. A boy gets his hand stuck in a vase; John rescues a kid in handcuffs. A man repairing a washer gets an electric shock. The paramedics rescue a man trapped on a crane.

Station 51 is called up to fight a wildfire. John and Roy rescue an elderly woman and her sister, treat an injured fireman, deliver a baby, catch a looter, and find a boy's lost dog.

John keeps losing at cards and being stuck with doing the dishes at the station, so he creates his own card game. Roy talks down a boy in a plane after the pilot (his father) has a heart attack. The paramedics respond to an attempted suicide, an overturned truck and a teenage overdose victim.

A store owner shoots an armed robber and is filled with remorse. Sparks fly between Johnny and a nurse. Dr. Early treats an alcoholic. A dog delays the rescue of an unconscious woman. Dr. Morton assumes an unconscious hippie is on drugs. The firemen rescue a man trapped at a chemical plant.

John is envious of the publicity given to another paramedic. After Roy and John rescue a man trapped in ship's rigging, John gets seasick. Dr. Brackett clashes with a tycoon over a diagnosis. The paramedics rescue a horse from a ditch and a child stuck in a well.

John is convinced that weird things will happen on their shift: a parachutist lands in a tree, an obese man collapses while jogging, an 80-year old woman breaks her ankle while dancing, a man can't stop the hiccups, a boy tries to cryogenically freeze himself, an golfer is bitten by a snake, a prostitute brings in a customer suffering from chest pains, and John is injured during the rescue of a drunk driver.

An elevator gets stuck between floors, and then the brake drum fails; inside, a man has a heart attack. A nursing student is in awe of Dr. Brackett; a fireman buff develops a crush on John, who tries to get rid of her. A man is injured in his junkyard. An industrial accident takes place at a railroad yard.

John and Roy bring in a football player who was tackled too hard. A burglar has a heart attack. John wants Roy to apologize for calling him ""some kind of nut."" Dr. Early treats a hypochondriac. A babysitter brings in a child who has swallowed some pills. Roy and John rescue the occupants of a light plane that crashed in a tree.