Lydia is forced to admit a patient who has the highly contagious Nipah virus when Ruby and new British-Asian doctor Samir Hasan break protocol in the fight to save the girl's life. Return of the medical drama set in a hospital in southern India.

The happy news that Karishma is awake is offset by her loneliness. Samir realizes she needs more than medicine to fix her and arranges a little magic. Meanwhile, Lydia discovers there's only one answer to Greg's visa problem.

A tragic case leads Samir and Mari to grow closer still. Lydia and Niki are reminded of how testing life can be as Good Karma Hospital doctors and a familiar face returns to Good Karma but will he find the forgiveness he's looking for?

Ruby is shocked with the unexpected arrival of someone from her past who insists on helping care for her father. Can she really be expected to trust again? A misstep teaches Niki the dangers of overconfidence and Lydia is forced to confront her past in the form of her first husband, the charismatic Dr. Jules Fonseca.

Lydia and Greg's wedding plans are upset by three emergency admissions. Greg wonders if disappearing to help her patients is a ploy and in truth, Lydia has cold feet. Will they tie the knot?